Endocrine Abstracts

Introduction: Alemtuzumab is a monoclonal antibody targeting the CD52 glycoprotein, which is expressed by most mature leucocytes. In early relapsing-remitting multiple sclerosis (MS) alentuzumab effectively decreases relapse rate and disability progression. However, nearly 50% of the pacients treated with alentuzumab develop secondary autoimmune disorders, being Graves’ disease the most common. The development of thyroid eye disease is unusual.Aims ...

A 52-year-old female patient with no previous history of interest, and with no prescribed habitual chronic treatment, was admitted to our hospital to be studied for symptomatic hypoglycemias of one month of evolution. Symptoms consisted of malaise, hunger, tremors and profuse sweating that disappeared with food ingestion. She referred hypoglycemic (up to 40 mg/dl) episodes daily, both in fasting and postprandial periods. She even suffered nocturnal episodes that woke her up. O...

Introduction: Malnutrition and sarcopenia are interrelated and frequent in hospital settings, being related to a higher morbimortality. CIPA nutritional screening (performed at the Hospital Universitario Nuestra Señora de Candelaria) is positive when one or more of the following criteria is met: a) decreased oral intake in 72 h (<50%), b) albumin <3 g/dl, and c) BMI <18.5 g/m2 or mid-upper arm circumference (MUAC) ≤ 22.5 cm.<p class="abste...

Introduction: Although meningiomas often occurs in parasellar regions such as the tuberculum sellae, olfactory groove, and sphenoid wing, pure intrasellar meningiomas are extremely rare. Patients usually present with gradual visual deterioration secondary to compression of the optic apparatus. Obtaining a correct preoperative diagnosis will likely require a thorough clinical assessment including neuroimaging and endocrine studies.Case report: A 56 year-o...

Introduction: The widespread use of highly-active antiretroviral therapy (HAART) has drastically improved the life expectancy of patients with human immunodeficiency virus (HIV) infection. However, many of these drugs show multiple interactions with other treatments; protease inhibitors (PI) are especially troublesome as they interact with the hepatic cytochrome P450. There have been previous reports of both Cushing’s syndrome and adrenal insufficiency in patients treated...

The Glucagon-like peptide-1 (GLP-1) receptor is expressed in the lung having a very important role in the modulation of the Angiotensin Converting Enzymes (ACEs). ACE1 cleaves angiotensin-I into angiotensin-II, which is converted by ACE2 to Ang(1-7). Ang(1-7) has vasodilating effects. The Idiopathic Pulmonary Fibrosis (IPF) is characterized by excessive extracellular matrix deposition disrupting the alveolar architecture and physiology. IPF develops by a sequence of inflammati...

The Glucagon-like peptide-1 receptor is widely expressed in diverse tissues including the liver. GLP-1 contributes itself to the regulation of glucose homeostasis and has important effects in lipid metabolism even preventing liver steatosis induced by high fat diets.The aim of this study was to analyse the short-term effects of liraglutide on key enzymes of the hepatic energy metabolism.Thirty-six Sprague-Dawley young adult male ra...

Adverse events during gestation in rodents, results in an enhancement of immune function, including elevated levels of inflammatory cytokines in the brain. Liraglutide is a GLP-1 receptor agonists known to exert neuroprotective effects in brain. The aim of this study was to elucidate if liraglutide given to food restricted (FR) pregnant rats may prevent the deleterious effects of FR in the hippocampal inflammatory status of male and female pups at 21 days of age (D21). 20 Spra...

Objective: Analyse the features of first patients treated with PCSK9 inhibitors in a specific Familial dyslipidemia Unit and the effects on lipid profile in first months of treatment.Material and methods: Data from patients with heterozygous familial hypercholesterolemia treated with PCSK9 inhibitors were reviewed. Clinical data, physical examination and analytical data were collected at baseline, one month and 3 months.Results: Da...

Introduction: A high percentage of patients diagnosed with Amyotrophic Lateral Sclerosis (ALS) have malnutrition. The nutritional treatment in ALS is essential, affecting muscle strength, quality of life and survival.Objective: To describe the nutritional characteristics of patients evaluated in a specific nutritional Unit in patients with ALS during 3 years.Material and methods: A descriptive study of all patients diagnosed with A...